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2018 Dec

El-sadawi etal, 2018

NNMT expression is significantly upregulated in white adipose tissue during obesity (3-5 fold) and increases with age across multiple tissues, creating a metabolic drain on both the NAD+ pool and the methylation budget

Mass spectrometry analysis reveals that CHCHD2 interacts with MICS1 (Meng et al., 2017), which is involved in cristae organization and cyt c stabilization, thereby prohibiting cells from apoptosis (Oka et al., 2008)

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