In order to protect itself, the cells in there change and toughen up. So Barretts is a structural change in the delicate lining of the esophagus, where the normal squamous cells get replaced by columnar cells, which are more resistant to acid, but unfortunately carry a slightly increased risk of cancer
It is about the habits we stack over time
Genetics and Environment: Combined Effects on Histamine Intolerance Genetic variants in the genes that encode the histamine-degrading enzymes are strongly linked to an increased relative risk of histamine intolerance
Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats
J Cell Biol 211:11031111 Colello D, Mathew S, Ward R, Pumiglia K, LaFlamme SE (2012) Integrins regulate microtubule nucleating activity of centrosome through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signaling