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Some natural anti-inflammatory agents (curcumin, resveratrol and quercetin) can act by modulating NF-B, STAT3 or MAPK signalling that may sensitize to chemotherapeutic treatments leading to protection from apoptosis when used inappropriately (210)

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A itself can generate ROS, creating a vicious cycle of oxidative stress and A accumulation

The Role of Glutathione in Circulation Healthy blood vessel function heavily relies on glutathione to maintain endothelial integrity

Furthermore, GBE can regulate the inflammatory response in blood vessels by decreasing the activity of the ROS producing enzyme, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX), and reducing the phosphorylation of mitogen-activated protein kinases (MAPKs)