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For Group A, a 3-step dose escalation regimen (Day 14: 0.06, Days 58: 0.12, Days 912: 0.16 and Days 1320: 0.2 mg, respectively) was chosen, Group B received 0.6 mg for 4 days, and 0.12 mg SAR425899 until Day 20

Data Availability The datasets generated during and or analyzed during the current study are available from the corresponding author on reasonable request

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The warmth many patients feel during treatment reflects this increased blood flow

When Cold Sensitivity Requires Medical Attention While mild cold sensitivity is expected and manageable, certain warning signs warrant immediate contact with your healthcare provider