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Set point resistance : Your body defends against further weight loss through hormonal shifts, including changes in leptin, ghrelin, and insulin sensitivity, that increase hunger and slow metabolism

Endocrinology 142:42444250 Dakin CL, Small CJ, Park AJ, Seth A, Ghatei MA, Bloom SR (2002) Repeated ICV administration of oxyntomodulin causes a greater reduction in body weight gain than in pair-fed rats

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Its effects can be enhanced by adding our NA-RA-ALA to the supplementation combo for weight loss stages to improve the capture and utilization of fat