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On-Label vs Off-Label and Compounded Products Vitamin B12 injections are an established medical treatment for confirmed B12 deficiency and related conditions (for example, pernicious anemia and certain malabsorption states), as summarized by the NIH Office of Dietary Supplements in its Vitamin B12 fact sheet for health professionals

Manufacturing, synthesis, testing, packaging, and fulfillment all take place within the continental United States

Dietz BM et al

Heffernan, M

There has not been a UL (upper intake level) established for B12 because it is not stored in your body and therefore, can not build up enough to cause serious adverse side effects for most people