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Nearly two-thirds of participants on Tirzepatide lost at least 20% of their baseline weight, a magnitude not previously seen with GLP-1only therapy (Jastreboff, New England Journal of Medicine )
References 1 AbbasT.FaivreE.HolscherC
This effect was observed without any impact on the marker expression of Lgr5 + stem cells, goblet cells, and Paneth cells
It belongs to a class of medicines known as GLP-1 receptor agonists, which help control appetite and blood sugar
It belongs to a novel class of agents known as triple agonists, meaning it simultaneously activates three distinct hormone receptors: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor
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