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The acquisition provided Roche with three clinical-stage assets with potential in treating obesity and diabetes
The Aib residue at position 2 and the fatty acid modification both confer resistance to the primary degradation enzymes (DPP-4 and neprilysin), extending the metabolic half-life
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doi: 10.1016/j.molmet.2021.101180 209 KellyPMcCleanPLAckermannMKonerdingMAHolscherCMitchellCA
DPP-4 inhibitors can on the other hand also be combined with an oral therapy with a SGLT-2 inhibitor (in dual combination when metformin is contraindicated or not tolerated or in triple therapy with metformin)
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