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Participants who received semaglutide injections lost significantly more weight than those on the placebo, with an average weight loss of around 15% of their initial body weight over the study period

doi: 10.1016/j.regpep.2012.08.009 21 CamilleriMVazquez-RoqueMIturrinoJBoldinghABurtonDMcKinzieSet al

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A 2025 FAERS (FDA adverse event reporting system) analysis found a reporting odds ratio of about 1.9 for depression with semaglutide

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