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Introduction Although nitric oxide (NO) has been posited as a deleterious molecule from a physiological perspective (Naseem, 2005), respiratory diseases (Soodaeva et al., 2020), neurodegenerative diseases (Snyder, 1992), and metabolic dysfunction ( In the context of exercise, nitrate supplementation has gained interest as an ergogenic aid to enhance endurance performance ( Therefore, the purpose of this review is to present the general knowledge of the underlying physiological mechanisms affected by NO and the subsequent effect of nitrate supplementation in exercise

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