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In summary, CZNPs target the root cause of oxidative stress, reshaping the ROSautophagymitochondria functional axis, and achieve multi-targeted intervention from signal perception to effect execution

Peer review Peer review information Nature thanks Darleen Sandoval and the other, anonymous, reviewer(s) for their contributions to the peer review of this work

In April 2026, the FDA granted approval to two oral GLP-1 treatments, Eli Lillys Foundayo, made with orforglipron, and Novo Nordisks semaglutide pill, also called Wegovy

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