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Maintaining a balanced diet and adequate hydration is important to minimize these effects while ensuring nutritional adequacy during weight loss

It remains to be seen how practical and cost effective daily supplementation of carnitine with carbohydrate is Carnitine and endurance exercise The belief that carnitine is an ergogenic aid for endurance exercise is based on assumptions similar to the weight-loss assumptions: Carnitine concentration in muscle becomes too low to allow the transport of carnitine into the mitochondria to function at a high velocity Oral ingestion of carnitine increases the total carnitine concentration in muscle Any increase in muscle carnitine increases the oxidation rate of plasma FAs and intramuscular triacylglycerols during exercise Any increase in fatty acids will reduce muscle glycogen breakdown and postponing fatigue

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For the most part, milk thistle is safe for short-term use at recommended doses, but safety beyond a few months has not been established