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In addition, superoxide anion may also react with nitric oxide (NO) to form peroxynitrite (ONOO - ), a potent ROS [1317]
These benefits likely stem from a combination of improved glycemic control and direct renoprotective mechanisms
If there is a lack of cobalamin in the body, methylmalonyl CoA accumulates, which presumably leads to the neurological manifestations of B12 deficiency.[4][7][9][12] The replenishment with parenteral cyanocobalamin causes a rapid and complete improvement of megaloblastic anemia and gastrointestinal symptoms caused by vitamin B12 deficiency
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Methods Considering the critical role of macrophages in HFD-induced obesity and inflammation, we generated mice with a macrophage-specific Grn depletion ( Grn -MKO mice) by mating lysozyme M (LysM)-Cre and Grn -floxed mice
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