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The measures included: Appendicular and trunk fat-free mass (proxy for lean muscle) Whole-body and trunk fat mass Body-fat percentage Waist-to-hip ratio Key Findings The researchers found that for every 1-unit reduction in BMI linked to GLP-1 mimicry: Fat mass decreased by ~7.9 kg Lean mass (muscle) decreased by ~6.4 kg Body-fat percentage dropped by ~4.5% In other words, fat loss exceeded muscle loss in both absolute and relative terms, which supports the use of GLP-1 drugs as a viable treatment for obesity
2020:F1000
The mechanism by which most drug interactions are determined is a system of liver enzymes called CYP450
Lets look at what clinical evidence shows and what it means in real life
When both pathways fire simultaneously, the pituitary somatotrophs release GH in quantities that far exceed the sum of what each peptide would produce individually
