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Niacinamide: At higher doses, temporary flushing or mild gastrointestinal symptoms may occur

The absence of formal contraindication does not equate to established safety or efficacy for combined use

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Individual results may vary based on lifestyle factors, diet, exercise, and overall health status

Herein, we showed that TGF-1 + IL-1 markedly induced fibroblast proliferation and differentiation by activating NLRP3 inflammasome