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Another possibly beneficial and important effect of DSIP is its importance in withdrawal from opioids, when, together with exogenously administered morphine, it was able to modulate opioid peptidergic systems, and in chronic pain, where the results of the study stated a significant reduction in pain attacks in patients with chronic pain and depressive states
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When it binds there, it reduces neuroinflammation, supports nerve fiber regrowth, and turns down the inflammatory signals that keep nerve pain going long after the original cause has resolved
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