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Abbreviations HCC: Hepatocellular carcinoma ROS: Reactive oxygen species MCs: Mitochondrial carriers MPCs: Mitochondrial pyruvate carriers ABC: ATP-binding cassette transporters MCCs: Mitochondrial citrate carriers MCUs: Mitochondrial Ca 2 uniporters GSH: Glutathione TCGA: The Cancer Genome Atlas ICGC: International Cancer Genome Consortium HCCDB: Hepatocellular Carcinoma Database KM: KaplanMeier LASSO: Least absolute shrinkage and selection operator ROC: Receiver operating characteristic t-SNE: t -distributed stochastic neighbor embedding scAtlasLC: Single-cell Atlas in Liver Cancer UMAP: Uniform manifold approximation and projection siRNA: Target small interfering RNA LCMS/MS: Liquid chromatography-tandem mass spectrometry KEGG: Kyoto Encyclopedia of Genes and Genomes GO: Gene Ontology GSEA: Gene set enrichment analysis CCK8: Cell counting kit-8 MMP: Mitochondrial membrane potential mPTP: Mitochondrial permeability transition pore NAC: N-acetyl-L-cysteine References Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al

It is the predominant intracellular non-protein thiol in mammalian tissues, present at concentrations typically ranging from 110 mM in the cytosol, with particularly high concentrations in the liver (up to 10 mM), which is the primary site of GSH synthesis and export

Structural model of ghrelin bound to its G protein-coupled receptor

All these amino acids are necessary for protein synthesis and collagen formation

Kraemer WJ et al