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La somministrazione cronica orale di alte dosi di levocarnitina in pazienti con grave compromissione della funzione renale o con insufficienza renale allo stadio terminale (ESRD) e dializzati pu indurre un accumulo dei metabolici potenzialmente tossici trimetilamina (TMA) e trimetilamina-N-ossido (TMAO), in quanto questi metaboliti vengono normalmente escreti con le urine
In this case, glutathione molecules are protected from this digestive breakdown and can enter the bloodstream and the cells intact
Clinical studies on treatment of diabetes in acromegaly have shown that a large percentage of patients achieved good glycaemic control with metformin in monotherapy or combined with other oral antidiabetic drugs (155)
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