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Concentration-response work suggests active concentrations in the range of 1 nanomolar to 1 micromolar

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OPFRs are widespread in air, water, and food, and their ingestion results in their presence in human blood and urine [431, 432]

Effect of vitamin C on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated early colon cancer in mice