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Heart In the SELECT trial (NEJM, 2023), weekly semaglutide 2.4 mg cut major adverse cardiovascular events by 20% in adults with overweight/obesity and established heart disease but no diabetes (6.5% vs 8.0% on placebo
However, patients should be aware of tirzepatide's effects on gastric emptying when scheduling procedures requiring anesthesia
Gastrointestinal discomfort
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