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Crafting a Rigorous, Clinically Relevant Large Animal Model of Chronic Myocardial Ischemia: What Have We Learned in 20 Years

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The percentages of participants who experienced AE leading to treatment discontinuation as well as of those who experienced gastrointestinal AE with oral semaglutide 50 mg (Tables 2 and 3) were similar to those observed with subcutaneous semaglutide 2.4 mg (in STEP-1 and STEP-2 trials 67% discontinued treatment due to AE, 3444% experienced nausea, 2132% diarrhoea and 2225% vomiting) [11, 29]

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Shin D, Lee J, You JH, Kim D, Roh JL

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Warning Signs to Watch For If you do choose to drink while on GLP-1 therapy, Agrawal advises stopping and seeking medical advice if you experience: Dizziness, confusion, sweating, shakiness, or slurred speech Severe or persistent nausea and vomiting Abdominal pain that could suggest pancreatitis Feeling unusually impaired despite drinking a small amount Worsened hangovers compared to your normal experience Trouble thinking clearly or coordinating movements Any of these symptoms are a reason to stop drinking and seek medical guidance, Agrawal says

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the Cochrane stroke review reports none and flags a safety signal

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