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Substitutions in the amyloidogenic core region were used to disrupt the beta-sheet propensity that drives fibril nucleation, allowing the analog to remain soluble and monomeric at formulation-relevant concentrations

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Mice from a different substrain and vendor, but fed similar lean and high-fat diets to this study, showed a predominance of the family Erysipelotrichaceae, of which Ileibacterium is a genus, in their cecal microbiomes 76

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