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Given the established clinical use of GLP-1RAs for the treatment of T2DM, preclinical and clinical research was centered largely around DR, which suggested the neuropathologic protective effects of GLP-1 are due to downregulation of NF-B, proinflammatory cytokines such as TNF-alpha and IL-1beta, and VEGF
Those with chronic inflammation may find that fasting helps reduce inflammatory indicators and strengthen antioxidant defenses
Recent technology, such as nanomedicine, further enhances tripeptide effects in many therapies
Together, these studies help shape safety protocols, particularly for patients with more complex CKD cases
NHS England and the Department of Health and Social Care have issued guidance prioritising existing patients and those with greatest clinical need
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