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In this model, iodine deficiency and Se deficiency exacerbate H2O2 accumulation, Se deficiency decreases cellular defense, promotes thyroid cell fibrosis, increases the inflammatory response following thyroid cell necrosis, and thiocyanate overload triggers follicular cell necrosis

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More recently, analysis using the Broad Institutes Connectivity Map database identified GHK as one of the top two compounds (from 1,309 bioactive molecules screened) recommended for study in aggressive metastatic colon cancer models, with GHK upregulating expression of numerous caspase genes and DNA repair genes associated with anti-cancer activity

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