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In a randomized controlled trial, 120 women with episodic migraines were randomly assigned to receive either 300 mg B1, 80 mg B6, 2 mg folic acid, 500 mcg B12, a combination of all of these B vitamins at the aforementioned dosages, or placebo daily for 12 weeks

The 2024 NICE guideline stresses tailoring the schedule to your symptoms and reviewing it, rather than treating one figure as fixed

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However, the FDA-approved dosing does not require adjustment based on body weight alone, suggesting these differences are not clinically significant within the therapeutic range

Lower AMH levels suggest declining fertility and may support a perimenopause diagnosis