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Before the first injection, obtain written confirmation of the exact dose, concentration, unit of measurement, injection site and technique, storage requirements, and the correct procedure for a missed or incorrectly measured dose

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Here, we present compelling results demonstrating a functional connection between altered TrkB signalling in iSPNs and changes in glutathione metabolism, particularly the enzyme GSTO2, at the pre-symptomatic stage, causing an early increase in DA followed by progressive degeneration and the onset of hyperkinetic symptoms

Early detection and continuous monitoring are critical for slowing the progression of this complication

DOI: 10.1056/NEJMoa2307563 Masharani U, Kroon L (2024): Pancreatic Hormones & Antidiabetic Drugs (Chapter 41)