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In light of evidence from animal models that brain GSH concentrations peak in the morning, 46 the single study visit was scheduled at 0700 hours for each participant in an attempt to control for circadian fluctuations

160 mg p=0.003) and dose-dependent increase of GLP-1 versus placebo control was detectable, even in the small patient population in this phase 1b clinical trial (baseline: N placebo = 11, N 80 mg IMU-856 = 13, N 160 mg IMU-856 = 13)

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