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Effect of body mass index on treatment response of biologic/targeted-synthetic DMARDs in patients with rheumatoid arthritis, psoriatic arthritis or axial spondyloarthritis

In 2-year rat carcinogenicity studies referenced in the Increlex label, increased mammary and skin tumor incidence occurred at high IGF-1 exposure

AD model mice suggested an increase in Hdac1/Hdac2, glycolysis/H4K12la/PKM2 signaling, and a decrease in Jmjd3, a histone H3K27me3 demethylase (Pan et al., 2022