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Consistent with this concept, GLP-1RAs have been shown to directly modulate immune responses by reducing the secretion of key pro-inflammatory cytokines such as IL-6 and TNF-, which are central drivers of inflammation in both PsO and PsA (70, 71)

Discontinuation due to adverse events was about 4% across all dose groups

Excess histamine can also damage the glycocalyxthe protective layer covering cellsleading to inflammation, gut dysbiosis, and higher risks of cardiovascular disease, diabetes, kidney disease, and stroke

As always, interactions and risks are possible with any supplement, so speak to a naturopathic doctor or other regulated healthcare provider before starting any new supplements.

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