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We understand that weight management is a complex process, and what works for one person may not work for another

Because overall weight reduction with retatrutide is greater than with other GLP-1 therapies, the absolute loss of lean mass may also be more substantial, which could have important implications in older, frail, and other high-risk patient populations

Growth hormone secretagogues as a class are on S2 because of the mechanistic potential to elevate growth hormone and downstream IGF-1, which are the same axes targeted by the banned growth hormone (S2.1) itself

Together, these medications affect brain pathways involved in appetite and food-related behaviors

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