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Abbreviations AEs: adverse events BC: body composition BHB: -hydroxybutyrate BIA: bioelectrical impedance analysis BIVA: bioelectrical impedance vector analysis BMI: body mass index BW: body weight CT: computed tomography CVD: cardiovascular disease FM: fat mass FFM: free fat mass GI: gastrointestinal GLP-1: glucagon-like peptide-1 GLP-1RA: glucagon-like peptide-1 receptor agonist HFpEF: heart failure with preserved ejection fraction KD: ketogenic diet LBM: lean body mass MASH: metabolic dysfunction-associated steatohepatitis MD: Mediterranean diet MEAL: Muscle maintenance, Energy balance, Avoid side effects, Liquid intake MM: muscle mass MNT: medical nutrition therapy MRI: magnetic resonance imaging PUFA: polyunsaturated fatty acids RCTs: randomised controlled trials SCFAs: short-chain fatty acids STEP: Semaglutide Treatment Effect in People with obesity T2D: type 2 diabetes TNF: tumor necrosis factor VLCKDs: very-low-calorie ketogenic diets VLEKT: very low energy ketogenic therapy WC: waist circumference WHO: World Health Organization References Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, et al

This energy deficit, while promoting weight loss, can result in fatigue, lightheadedness, and generalized weakness, particularly during the initial weeks of treatment or after dose escalation

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GLP-1 receptor agonists are effective treatment options for managing blood sugar levels and promoting weight loss in patients who suffer from type 2 diabetes and obesity