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Development for the obesity indication was discontinued in 2007 as a direct result of that Phase IIb outcome

Key distinctions matter because they guide evaluation: a globus sensation without difficulty swallowing or breathing is usually benign, whereas actual trouble swallowing (dysphagia), pain when swallowing (odynophagia), or any breathing difficulty should prompt faster medical assessment

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The inflammatory microenvironment reduces the glutamate uptake, inducing accumulation of this excitatory amino acid and excitotoxic neurodegeneration