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The FLOW (Evaluate Renal F unction with Semag l utide O nce W eekly) study is a double-blind, randomised, placebo-controlled international trial comprising 3,533 patients, with a median follow-up period of 3.4 years
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In one study, adjusted odds ratios for MASLD demonstrated a clear gradient: lowest in never smokers, higher in exclusive cigarette smokers, and highest among dual users, suggesting an additive or even synergistic effect of combined exposure [140]
Therefore, more participants and longer follow-up time may better reflect the relationship between the use of GLP-1RAs and the risk of respiratory disease
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