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Semaglutide and tirzepatide are typically recommended along with lifestyle changes, such as a reduced-calorie diet and increased physical activity
GLP-1 receptor agonists should be considered when patients experience significant weight regain with BMI 27 kg/m with obesity-related comorbidities or BMI 30 kg/m, lifestyle modifications have been insufficient, no anatomical complications require surgical revision, and patients are willing to engage in long-term pharmacotherapy
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These lifestyle modifications, along with the initial weight loss achieved with semaglutide GLP-1, can have a lasting positive impact on health and well-being
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