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Other recent research has highlighted two promising non-peptide compounds, TTOAD2 and orforglipron, she said

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In experimental models, they preserved dopaminergic neurons and improved motor performance via mitochondrial and endoplasmic reticulum stress pathways (Sedky and Magdy, 2021)

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[1] [2] When neurological symptoms are present such as paraesthesia, numbness, balance problems, or cognitive changesmore aggressive treatment is required