During this stage, 300 articles were excluded due to irrelevance to the research question or failure to meet the inclusion criteria (22 clinical trials, 43 reviews or other unfitting literature, 112 wrong cell type, 49 wrong focus, 10 wrong drugs, 57 in vivo, 2 retractions, 3 no abstract and 2 not peer reviewed yet)
IPA accumulation demonstrates biphasic mitochondrial regulation: acute exposure (30 min) enhances maximal mitochondrial respiratory capacity, while chronic exposure (24 h) significantly inhibits complexes I/II/IV activity and fatty acid oxidation, reducing oxygen consumption rates (Gesper et al., 2021)
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Beyond influencing brain signals, semaglutide GLP-1 also slows down the stomachs emptying process, extending the sensation of fullness and minimizing the tendency to overeat or snack between meals