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Notably, rhamnose-induced expression triggered significant growth defects (30%45% biomass reduction), particularly in LCC-expressing strains, which might highlight the enzyme-specific cytotoxicity
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The accumulation of lactate within the cell is managed by the upregulation of monocarboxylate transporters (MCTs), particularly MCT4, which facilitates lactate efflux into the extracellular space (72)
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Interestingly, the cuprotosis approach to cell death caused by the tricarboxylic acid cycle is similar to ferroptosis, in that ferroptosis also involves mitochondrial dysfunction and the production of excess acetyl-CoA
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