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Circulating Fe 3+ enters cells with the assistance of transferrin and subsequently converts to Fe 2+ ( 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Figure 4)
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The first dose was taken upon wakingideally 3060 min before the first mealand the second dose in the afternoon, approximately 2 h before nighttime sleep, irrespective of dinner timing
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