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A10 M concentration of icariin, a PDE5-I, has the ability to raise nitric oxide synthase in the corpus cavernosum tissue of diabetic rats that are experiencing erectile dysfunction (ED), which may increase cellular cGMP levels [112]

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The use of hydrophobic polymers such as poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) in oral tablets and enzyme inhibitors may show potential for improving the oral bioavailability of GLP-1 agonists

Curr Opin Cell Biol 32:121130

doi: 10.1056/NEJMoa1504720 57 WiviottSDRazIBonacaMPMosenzonOKatoETCahnAet al