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In a study of colon cancer cells, COX-2 expression and PGE2 synthesis were upregulated by the IGF-2/IGF-1R autocrine pathway and IGF-1R blockade decreased COX-2 activity and inhibited tumor cell proliferation and promoted apoptosis (103)

IMM, inner mitochondrial membrane

Our study revealed pronounced oxidative stress in mice exposed to APAP, which contrasts with previous research showing that mimic peptides targeting necrotic cells in APAP-induced hepatotoxicity do not significantly alter liver oxidative status or GSH level (Maes et al

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Days 1-3 bring the most swelling and bruising