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Because copper itself has a narrow physiological range, protocols involving repeated or high-frequency application in animal models often include copper-load monitoring alongside the primary remodeling endpoints, to rule out confounding from excess trace-mineral exposure rather than peptide-specific signaling

Administration is simple enough for self-injection after initial instruction

10.1016/j.ejphar.2003.08.013 11 Belosic HalleZ.VlainicJ.DrmicD.StrinicD.LueticK.SucicM.et al (2017)

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Indeed, these studies are burdened by several limitations, most importantly the small sample size and the lack of evaluation of the therapeutic effect of GSH by liver biopsy, which to date is the gold standard for the definition of steatosis and fibrosis levels