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Transcriptional regulation of the human cystathionine beta-synthase -1b basal promoter: synergistic transactivation by transcription factors NF-Y and Sp1/Sp3

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As a future direction, we propose testing whether, in the absence of Trim37 , PGCs progressively lose intrinsic germline determinants and fail to stabilize a coherent somatic identity because they do not receive appropriate lineage-specifying cues, ultimately resulting in elimination through cell death

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