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Long-term observational studies and real-world evidence continue to accumulate

Some programs require documented comorbidities like hypertension or sleep apnea before approving coverage, and a growing number now demand genetic testing or documented weight loss program participation

This drug differs from the previously approved liraglutide in that semaglutide has been shown to be more effective in promoting weight loss

Several studies have shown that tirzepatide reduces insulin resistance, improves glycemic control, and lowers inflammatory biomarkers, including C-reactive protein and IL-6 (46, 47)