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In this article, we will review incretin physiology and evidence supporting a role of the incretin hormones in the pathophysiology of hyperinsulinemic hypoglycemia, as well as results from proof-of concept studies exploring a therapeutic approach targeting the GLP-1 receptor to treat hyperinsulinemic hypoglycemia
All analyses were performed using GraphPad Prism 7 for Windows, version 7.04 (GraphPad Software, La Jolla, CA)
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Designing probes that can produce different reaction products or bind specifically to GSH rather than Cys and Hcy can help improve specificity
In more severe cases, especially those with clear symptoms of delayed gastric emptying, I have also introduced Gimoti - which has made a real difference for some as well
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