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MHRA Updated semaglutide guidance including NAION warning (GOV.UK, February 2026) 10

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The reduction in hepatic steatosis occurred alongside improvements in liver enzymes, with ALT and AST levels declining from baseline, indicating reduced hepatocellular inflammation and improved liver health

Weight regain after stopping is a documented pattern with all GLP-1 class compounds, and Retatrutide is expected to follow the same pattern

Further research is required to establish the efficacy of GHRP-2 peptide before it can be approved for human consumption