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all P -values are reported in Supplementary Table 1 and source data are available in the Dryad repository doi:10.5061/dryad.905qfttvz)

A study demonstrated that the deletion of SIRT1 in hepatocytes leads to increase in PGC-1 acetylation levels disrupted PPAR- signaling followed by a decrease in fatty acid -oxidation, hepatic steatosis, liver inflammation, and ER stress 55,59

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While iron-based Fenton reactions produce hydroxyl radicals (OH), their effectiveness requires an acidic environment, prompting exploration of metals like Mn and Cu that offer superior catalytic performance [76]