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The proposed mechanism involves Epithalon's interaction with pinealocyte transcriptional machinery governing the rate-limiting enzymes in the melatonin synthesis pathway: arylalkylamine N-acetyltransferase (AANAT) and hydroxyindole-O-methyltransferase (HIOMT)

Sebacia works to reduce oil production, so it works best when paired with treatments that address the other underlying causes

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Compounding allows the prescriber to fine-tune retinoid strength based on patient tolerance and to add agents like niacinamide for barrier supportcombinations not available in any single commercial product

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