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With respect to metabolic and regulatory mechanisms, cells undergoing ferroptosis sustain changes in iron metabolism, lipid peroxidation formation, ROS production, and the glutathione/FSP1 antioxidant system

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In addition, the calcium-independent phospholipase iPLA2 has been identified as a target gene of p53 that suppresses ferroptosis by detoxifying peroxidized lipids under mild stress conditions (Fig

Science 322 , 12471250 (2008)