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Commonly reported side effects in the Phase 2 trial included: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea Constipation Decreased appetite Abdominal discomfort or bloating Eructation (belching) The majority of participants who discontinued treatment did so due to gastrointestinal side effects, underscoring the importance of the slow titration schedule used in trials
Ipamorelin (a ghrelin mimetic): Triggers GH release by mimicking ghrelin , stimulating a pulse-like release of GH without raising cortisol or prolactin
We also observed no changes in motor neuron counts or glial activation in lumbar spinal cords of liraglutide treated mice compared to vehicle dosed mice
Available GLP-1s include semaglutide (Ozempic/Wegovy active ingredient) and tirzepatide (Mounjaro/Zepbound active ingredient, also targets GIP receptors)
The Role of Healthy Habits in Weight Maintenance While GLP-1 medications can help regulate appetite and blood sugar, sustainable weight management relies on building healthy habits
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