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Our data suggest exendin-P5 may induce a looser coupling between the ligand TMD and G s binding sites, potentially linked to the more short-lived interactions with TMD residues, resulting in higher efficacy due to faster G s conformational transitions associated with nucleotide exchange and faster G s dissociation
TC, total cholesterol
Reduced regional cerebral blood flow in patients with heart failure
Two compounds binding the same receptor do not necessarily produce the same downstream profile the binding conformation determines which coupled signaling pathways are preferentially activated
Growth hormone pathway studies: Examination of receptor-specific signaling mechanisms
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